What is DanioVision? A brief insight in zebrafish tracking
In this blog we provide a quick refresh on the topic of zebrafish, and how DanioVision contributes to this field.
Read More arrow_forwardDid you know that zebrafish larvae are able to detect minute movement in the water and that zebrafish are better than fruit flies? Read all four facts!
Did you know that zebrafish larvae are able to detect minute movement in the water and that zebrafish are better than fruit flies? Read all four facts!
At the Max Planck Institute in Germany, Groneberg and colleagues (Groneberg et al. 2015) showed that larval zebrafish show approach reactions followed by a form of positive taxis and gradual motion damping in response to water flows. That might sound complicated, but what it basically means is that zebrafish larvae are able to detect minute movement in the water and respond in a stereotypical way.
Prof. Richard Baines' lab investigates how the electrical development of neurons is regulated. His research was long based on the larvae of fruitfly, but the lab recently started using zebrafish larvae. The Baines lab at the University of Manchester has recently begun to use the DanioVision system to identify novel anticonvulsive compounds. The Baines group have identified a number of novel compounds that have the potential to become next-generation antiepileptics.
Currently, advances in data-processing, high-resolution cameras, calibration methods, and a combination of highly advanced software programs provide a reliable way to track the movement of zebrafish in X,Y, and Z coordinates, as the Kalueff Lab reports (Stewart et al., 2015). 3D tracking results were compared to manual observations of zebrafish behavior in a novel tank test, post application of the psychotropic drugs nicotine, LSD, and PCP.
Researchers at the University of Toronto Mississauga in the Gerlai lab use zebrafish to unravel the mysteries of alcohol addiction. Similar to humans and rodents, the neurochemical dopamine was found to play a large role in regulating alcohol's locomotor stimulant effects in zebrafish.
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In this blog we provide a quick refresh on the topic of zebrafish, and how DanioVision contributes to this field.
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Depression: a fifth (!) of us cope with it, making it the most prevalent psychiatric disorder. Prof. Gerlai recently investigated the interaction between mild stress and developmental isolation in zebrafish models.
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Teresa Capriello and colleagues use zebrafish to study the neuronal mechanisms of heavy metals in connection to neurodegenerative and neuromuscular diseases.
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