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Resources and publications

EthoVision is the most widely applied video tracking software that tracks and analyzes the behavior, movement, and activity of any animal.

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EthoVision
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EthoVision

Selected publications

EthoVision is the preferred behavioral tool for scientists that publish in high impact journals.

  • Sulukan, E. et al. (2023). Global warming and glyphosate toxicity (II): Offspring zebrafish modelling with behavioral, morphological and immunohistochemical approaches. Science of The Total Environment, 856 (1). https://doi.org/10.1016/j.scitotenv.2022.158903
  • Caporale, N. et al (2022). From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures. Science, vol 375 issue 6582. https://doi.org/10.1126/science.abe8244
  • Rehman, S. et al (2022). Developmental defects and behavioral changes in a diet-induced inflammation model of zebrafish. Frontiers in Immunology, volume 13 - 2022. https://doi.org/10.3389/fimmu.2022.1018768
  • Johnson, A. et al (2023). Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish. Scientific reports, volume 13, Article number: 3768 (2023). https://doi.org/10.1080/00140139.2022.2157493.
  • Singh, H. et al (2022). Learning Deficits and Attenuated Adaptive Stress Response After Early-Life Seizures in Zebrafish. Frontiers in Neuroscience, Volume 16 - 2022. https://doi.org/10.3389/fnins.2022.869671
  • Gabellini, C. et al (2022). CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences, 2023, 24(1), 167. https://www.mdpi.com/1422-0067/24/1/167
  • Zheng, J. et al (2022). Knockout of Katnal2 Leads to Autism-like Behaviors and Developmental Delay in Zebrafish. International Journal of Molecular Sciences, 2022, 23 (15). https://doi.org/10.3389/frcha.2023.1214890
  • Birnie, M.T. et al (2023). Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice. Nature Communications, 14, Article number: 1088. https://doi.org/10.1038/s41467-023-36780-x
  • Byun, Y., & Noh, J. (2024). Social play exclusion model in adolescent rats: Monitoring locomoter and emotional behavior associated with social play and examining c-Fos expression in the brain. Physiology & Behavior, 273, Article number: 114379. https://doi.org/10.1016/j.physbeh.2023.114379
  • Oh, H. et al (2023). Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nature Communications, 14, Article number: 3547. https://doi.org/10.1038/s41467-023-39203-z
  • Liu, J. et al (2022). GW4064 Alters Gut Microbiota Composition and Counteracts Autism-Associated Behaviors in BTBR T+tf/J Mice. Frontiers in Cellular and Infection Microbiology, Volume 12 - 2022. https://doi.org/10.3389/fcimb.2022.911259
  • Cassidy, B.R. et al (2023). Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection. Frontiers in Immunology, volume 14 - 2023. https://doi.org/10.3389/fimmu.2023.1146690
  • Cassidy, B.R. et al (2023). Systemic infection of mice with neuroinvasive Listeria monocytogenes triggers cognitive decline and persistent increases in brain CD8+ T-lymphocyte populations. Journal of Affective Disorders Reports, Volume 12 (100536). https://doi.org/10.1016/j.jadr.2023.100536
  • Hendrickx, J.O. et al (2022). Age-related cognitive decline in spatial learning and memory of C57BL/6J mice. Behavioral Brain Research, Volume 418. https://doi.org/10.1016/j.bbr.2021.113649
  • Williams, Z.A.P. et al (2023). Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice. Brain, Behavior, & Immunity - Health, Volume 30 (100628). https://doi.org/10.1016/j.bbih.2023.100628
  • Xu, N. et al (2022). Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats. Frontiers in Immunology, volume 13 - 2022. https://doi.org/10.3389/fimmu.2022.873382
  • Kafle, B.D., Bernal, J.S. & Fadamiro, H.Y. (2025). Three-dimensional flight analysis shows associative learning enhances foraging behavior of the specialist parasitoid, Microplitis croceipes. Entomologia Experimentalis et Applicata 00, 1–10. https://doi.org/10.1111/eea.13560
  • Ilie, O. D., Duta, R., Jijie, R., Nita, I. B., Nicoara, M., Faggio, C., Dobrin, R., Mavroudis, I., Ciobica, A., & Doroftei, B. (2022). Assessing Anti-Social and Aggressive Behavior in a Zebrafish (Danio rerio) Model of Parkinson’s Disease Chronically Exposed to Rotenone. Brain Sciences, 12(7), 898. https://doi.org/10.3390/brainsci12070898
  • Jijie, R., Solcan, G., Nicoara, M., Micu, D., & Strungaru, S. A. (2020). Antagonistic effects in zebrafish (Danio rerio) behavior and oxidative stress induced by toxic metals and deltamethrin acute exposure. Science of the Total Environment, 698, 134299. https://doi.org/10.1016/j.scitotenv.2019.134299
  • Hinze, A., Lantz, J., Hill, S. R., & Ignell, R. (2021). Mosquito host seeking in 3D using a versatile climate-controlled wind tunnel system. Frontiers in behavioral neuroscience, 15, 643693. https://doi.org/10.3389/fnbeh.2021.643693

Most-Cited EthoVision Publications

EthoVision has been cited in over 35,000 peer-reviewed publications since 1995. Below are the foundational methodology papers and high-impact research from Nature, Cell, and leading neuroscience journals that relied on EthoVision for behavioral tracking and analysis.

Foundational Research on EthoVision

The methodology and validation papers that established EthoVision as the standard tool for automated behavioral tracking.

EthoVision: A versatile video tracking system for automation of behavioral experiments

Noldus LPJJ, Spink AJ, Tegelenbosch RAJ

Behavior Research Methods, Instruments & Computers, 33, 398-414 (2001)

Cited 4,200+ times. The foundational paper introducing EthoVision for automated behavioral analysis.

format_quote4,200+

The EthoVision video tracking system: a tool for behavioral phenotyping of transgenic mice

Spink AJ, Tegelenbosch RAJ, Buma MOS, Noldus LPJJ

Physiology & Behavior, 73(5), 731-744 (2001)

Cited 890+ times. Validation of EthoVision for phenotyping transgenic mouse models in neuroscience.

format_quote890+

Computerised video tracking, movement analysis and behaviour recognition in insects

Noldus LPJJ, Spink AJ, Tegelenbosch RAJ

Computers and Electronics in Agriculture, 35(2-3), 201-227 (2002)

Cited 520+ times. Extension of EthoVision tracking to insect behavior and entomology research.

format_quote520+

High-Impact Research Using EthoVision

Landmark studies published in Nature, Cell, and top neuroscience journals that chose EthoVision for behavioral data collection and analysis.

Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

van Praag H, Shubert TE, Zhao C, Gage FH

Journal of Neuroscience, 25(38), 8680-8685 (2005)

Cited 2,096 times. Used EthoVision to measure locomotor activity and spatial learning in the Morris water maze.

format_quote2,096

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Kravitz AV, Freeze B, Parker PRL, Kay K, Thwin MT, Deisseroth K, Kreitzer AC

Nature, 466, 622-626 (2010)

Cited 1,931 times. Published in Nature. Used EthoVision to quantify motor behavior changes in optogenetically manipulated mice.

format_quote1,931

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6

Smith SEP, Li J, Garbett K, Mirnics K, Patterson PH

Journal of Neuroscience, 27(40), 10695-10702 (2007)

Cited 1,634 times. Used EthoVision for open field and social interaction behavioral testing in autism models.

format_quote1,634

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, et al.

Cell, 177(6), 1600-1618 (2019)

Cited 1,196 times. Published in Cell. Used EthoVision for comprehensive behavioral phenotyping of gnotobiotic mice.

format_quote1,196

Sodium oligomannate remodels gut microbiota and suppresses neuroinflammation to inhibit Alzheimer's disease progression

Wang X, Sun G, Feng T, Zhang J, Huang X, et al.

Cell Research, 29, 787-803 (2019)

Cited 1,138 times. Published in Cell Research. Used EthoVision for Morris water maze spatial memory assessment in Alzheimer's models.

format_quote1,138

Epigenetic Transmission of the Impact of Early Stress Across Generations

Franklin TB, Russig H, Weiss I, Graff J, Linder N, Mansuy IM

Biological Psychiatry, 68(5), 408-415 (2010)

Cited 1,121 times. Used EthoVision for elevated plus maze and open field anxiety-related behavioral testing.

format_quote1,121

Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects

Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, et al.

Biological Psychiatry, 82(7), 472-487 (2017)

Cited 953 times. Used EthoVision for tail suspension, forced swim, and social interaction behavioral assessments.

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Citation data from OpenAlex (August 2026). EthoVision XT has been cited in 35,000+ peer-reviewed publications across 4,000+ research sites worldwide since 1995.

Trusted partners, ethical standards, and expert webinars

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Ethics in animal testing

Ethics in animal testing

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Expert webinars

Expert webinars

Watch webinars from experts in animal behavior research and learn how to get the most out of EthoVision.

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