CatWalk XT 11 - Analyze Data - Genetic/Toxic Models
Last updated: Jul 28, 2026
Genetic/Toxic Models
Huntington's Disease
Vandeputte, C., Taymans, J.-M., Casteels, C., Coun, F., Ni, Y., Van Laere, K., Baekelandt, V. 2010. Automated quantitative gait analysis in animal models of movement disorders. BMC Neuroscience 11: 92. doi: 10.1186/1471-2202-11-92.
Parameters affected: Swing Speed, Stand.
Refsum Disease
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Ferdinandusse, S., Zomer, A.W.M., Komen, J.C., van den Brink, C.E., Thanos, M., Hamers, F.P.T., Wanders, R.J.A., van der Saag, P.T., Poll-The, B.T., Brites, P. 2008. Ataxia with loss of Purkinje cells in a mouse model for Refsum disease. PNAS 105: 17712–17717. doi: 10.1073/pnas.0806066105.
Parameters affected: Print Area, Toe Spread of intermediate toes, Base of Support. Unsteady gait with strongly reduced paw print area for both fore- and hindpaws and reduced base of support for the hindpaws.
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Lucas, E.K., Reid, C.S., McMeekin, L.J., Dougherty, S.E., Floyd, C.L., Cowell, R.M. 2014. Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α. Frontiers in Cellular Neuroscience 8: 441. doi: 10.3389/fncel.2014.00441.
Parameters affected: Print Area, Swing Speed, Stand Index, Regularity Index.
Charcot-Marie-Tooth (CMT)
Villalón, E., Dale, J.N., Jones, M., Shen, H., Garcia, M.L. 2015. Exacerbation of Charcot-Marie-Tooth type 2E neuropathy following traumatic nerve injury. Brain Research 1627: 143–153. doi: 10.1016/j.brainres.2015.09.024.
Parameters Affected
Print Length and Width, Max Contact Area, Max Intensity, Max Contact at (%), all decreased. Couplings involving the affected limb (LH) decreased or increased depending on the coupling combination.
References
- Dale, J.M., Villalon, E., Shannon, S.G., Barry, D.M., Markey, R.M., Garcia, V.B. and Garcia, M.L. 2012. Expressing hNF-LE397K results in abnormal gaiting in a transgenic model of CMT2E. Genes, Brain and Behavior 11: 360–365. doi:10.1111/j.1601-183X.2012.00771.x
- Parameters affected: Stride Length, Regularity Index, Stand Index (all decreased). Couplings and Phase dispersions increased or decreased depending on which combination was considered.
Leigh Disease
- de Haas, R., Russel, F.G., & Smeitink, J.A. 2016. Gait analysis in a mouse model resembling Leigh disease. Behav Brain Res, 296: 191–198.
Source: CatWalk XT 11.0 Reference Manual - Analyze Data, Noldus Information Technology