CatWalk XT 11 - Analyze Data - Parkinson's Disease Models
Last updated: Jul 26, 2026
Parkinson's Disease Models
Results Summary
| Result | Parameters Affected | References |
|---|---|---|
| Treatment improved motor functions as measured with CatWalk XT | Run Average Speed, Regularity Index, Print Area, Swing Speed, Stride Length, Print Positions | Tatenhorst et al. 2016 |
| Treatment improves speed of locomotion but impairs forelimb movement | Run Duration, Base of Support, Maximum Contact Area, Maximum Intensity, Swing Duration, Swing Speed | Vlamings et al. 2016 |
| Behavioral deficits efficiently measured in rat Parkinson models | Mean Intensity, Maximum Contact Area (forepaws) | Vandeputte et al. 2010 |
| Swaying pattern during locomotion was quantified in rodent models | Paw statistics X position and Y position | Timotius et al. 2018 |
| Detection of motor deficiencies in a Medial Forebrain Bundle 6-OHDA lesion model of Parkinson's disease | Stride Length, Print Position, Step Cycle, Swing phase of the step cycle, Stand index, Phase Dispersion, Print Length, Print Area | Boix et al. 2018 |
References
- Boix, J., von Hieber, D., Connor, B. 2018. Gait analysis for early detection of motor symptoms in the 6-OHDA rat model of Parkinson's disease. Frontiers in Behavioral Neuroscience 12: 39.
- Tatenhorst, L., Eckermann, K., Dambeck, V., Fonseca-Ornelas, L., Walle, H., Lopes da Fonseca, T., Koch, J.C., Becker, S., Tönges, L., Bähr, M., Outeiro, T.F., Zweckstetter, M., Lingor, P. 2016. Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 4: 39. doi: 10.1186/s40478-016-0310-y
- Timotius, I.K., Canneva, F., Minakaki, G., Pasluosta, C., Moceri, S., Casadei, N., Riess, O., Winkler, J., Klucken, J., von Hörsten, S., Eskofier, B. 2018. Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter. Journal of Neuroscience Methods 296: 1–11. doi: 10.1016/j.jneumeth.2017.12.004
- Vandeputte, C., Taymans, J.-M., Casteels, C., Coun, F., Ni, Y., Van Laere, K., Baekelandt, V. 2010. Automated quantitative gait analysis in animal models of movement disorders. BMC Neuroscience 11: 92. doi: 10.1186/1471-2202-11-92
- Vlamings, R., Visser-Vandewalle, V., Koopmans, G., Joosten, E.A.J., Kozan, R., Kaplan, S., Steinbusch, H.W.M., Temel, Y. 2007. High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats. Neuroscience 148: 815–823. doi: 10.1016/j.neuroscience.2007.06.043
Sciatic Nerve Injury
Results Summary
| Result | Parameters Affected | References |
|---|---|---|
| CatWalk gait analysis suitable for the measurement of behavioural recovery after complete rat sciatic nerve injury | Paw Print Intensities, Couplings | Bozkurt et al. 2008 |
| A review of the most important gait kinematic measures that can be gathered with automated gait analysis systems | — | Costa et al. 2011 |
| CatWalk gait analysis detects a large set of both dynamic and static gait changes after neurotmesis (complete nerve transection) | Base of Support, Print Length, Print Width, Stride Length, Maximum Area, Mean Intensity, Stand Duration, Swing Duration, % of normal step sequence patterns, Phase Dispersion (girdles and ipsilateral left side) | Deumens et al. 2007 |
References
- Bozkurt, A., Deumens, R., Scheffel, J., O'Dey, D.M., Weis, J., Joosten, E.A., Führmann, T., Brook, G.A., Pallua, N. 2008. CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury. Journal of Neuroscience Methods 173: 91–98. doi: 10.1016/j.jneumeth.2008.05.020
- Costa, L.M., Simões, M.J., MaurĂcio, A.C., VarejĂŁo, A.S.P. 2009. Chapter 7: Methods and protocols in peripheral nerve regeneration experimental research: Part IV — Kinematic gait analysis to quantify peripheral nerve regeneration in the rat. International Review of Neurobiology 87: 127–139. doi: 10.1016/S0074-7742(09)87007-4
- Deumens, R., Jaken, R.J.P., Marcus, M.A.E., Joosten, E.A.J. 2007. The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection. Journal of Neuroscience Methods 164: 120–130. doi: 10.1016/j.jneumeth.2007.04.009
Arthritis
Monoarthritis
Möller, K.Ä., Berge, O.-G., Hamers, F.P.T. 2008. Using the CatWalk method to assess weight-bearing and pain behaviour in walking rats with ankle joint monoarthritis induced by carrageenan: Effects of morphine and rofecoxib. Journal of Neuroscience Methods 174: 1–9. doi: 10.1016/j.jneumeth.2008.06.017.
Parameters affected: Print Area, Mean Intensity (as a measure of weight load), Duty Cycle, Regularity Index (all decreased in treated animals).
Osteoarthritis
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Ferreira-Gomes, J., Adaes, S., Castro-Lopes, J.M. 2008. Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study. The Journal of Pain 9: 945–954.
Parameters affected: Total Intensity (calculated outside CatWalk).
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Ishikawa, G., Nagakura, Y., Takeshita, N., Shimizu, Y. 2014. Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis. European Journal of Pharmacology 738: 111–117. doi: 10.1016/j.ejphar.2014.05.048.
Parameters affected: Maximum Contact Area, Swing Speed.
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Qin, J., Chow, S.K.-H., Guo, A., Wong, W.-N., Leung, K.-S., Cheung, W.-H. 2014. Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect induced osteoarthritis rat model. Osteoarthritis and Cartilage 22: 1061–1067. doi: 10.1016/j.joca.2014.05.004.
Parameters affected: Duty Cycle, Regularity Index.