CatWalk XT 11 - Analyze Data - Ischemia / Stroke
Last updated: Jul 26, 2026
Ischemia / Stroke
- Long-term functional deficit after middle cerebral artery occlusion. Parameters affected: Swing Speed, Intensity, Duty Cycle, Phase Dispersions. (Encarnacion et al. 2011)
- After photothrombosis lesion, gait is affected in various ways. Parameters affected: Average Speed, Cadence, Stand and Swing Duration, Support, Maximum Contact Area, Max Intensity at Max Contact, Couplings. (Madinier et al. 2014)
- Gait analysis reveals impairments in the limbs of both sides after right middle cerebral artery occlusion, and suggests involvement of the contralesional left hemisphere in recovery. Parameters affected: Regularity Index, Maximum Contact Area, Mean Intensity, Stride Length, Swing Speed. (Qin et al. 2014)
References
- Encarnacion, A., Horie, N., Keren-Gill, H., Bliss, T.M., Steinberg, G.K. & Shamloo, M. 2011. Long-term behavioral assessment of function in an experimental model for ischemic stroke. Journal of Neuroscience Methods 196: 247–257. doi:10.1016/j.jneumeth.2011.01.010
- Madinier, A., Quattromani, M.J., Sjölund, C., Ruscher, K. & Wieloch, T. 2014. Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke. PLoS ONE 9: e93121. doi:10.1371/journal.pone.0093121
- Qin, L., Jing, D., Parauda, S., Carmel, J., Ratan, R.R., Lee, F.S., Cho, S. 2014. An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke. Journal of Neuroscience 34: 2493–2502. doi:10.1523/JNEUROSCI.4140-13.2014
Amyotrophic Lateral Sclerosis (ALS)
Results Summary
| Result | Parameters Affected | References |
|---|---|---|
| Gait parameters describe decline in motor function in a transgenic mouse model of ALS | Stand, Stride Length, Duty Cycle, Support on diagonal limbs, Support on 3 limbs | Mead et al. 2011 |
| Stem cell treatment improves motor function | Stride Length (hindlimbs) | Sun et al. 2014 |
| Altered gait in mouse with ALS-related gene | n.a. | Vergouts et al. 2015 |
References
- Mead, R.J., Bennett, E.J., Kennerley, A.J., Sharp, P., Sunyach, C., Kasher, P., Berwick, J., Pettmann, B., Battaglia, G., Azzouz, M., Grierson, A., Shaw P.J. 2011. Optimised and rapid pre-clinical screening in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS). PLoS ONE 6: e23244. doi: 10.1371/journal.pone.0023244
- Sun, H., Hou, Z., Yang, H., Meng, M., Li, P., Zou, Q., Yang, L., Chen, Y., Chai, H., Zhong, H., Zhuyun Yang, Z., Zhao, J., Lai, L., Jiang, X., Xiao Z. 2014. Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model. Cell Tissue Research 357: 571. doi: 10.1007/s00441-014-1903-z
- Vergouts, M., Marinangeli, C., Ingelbrecht, C., Genard, G., Schakman, O., Sternotte, A., Calas, A.-G., Hermans, E. 2015. Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease. Metabolic Brain Disease 30: 1369. doi: 10.1007/s11011-015-9706-9
Cerebellar Ataxia
Results Summary
| Result | Parameters Affected | References |
|---|---|---|
| Impaired gait in general as a result of neurological deficits | Swing Duration, Stand Duration, Regularity Index | CendelĂn et al. 2010 |
| Motor abnormalities measured after suppression of the P/Q-type calcium channels in Purkinje neurons | Print Area, Stand, Duty Cycle, Stride Length | Salvi et al. 2014 |
| Static and dynamic parameters showed significant differences in three rat models of impaired coordination and ataxia | Average Speed, Swing Speed, Stride Length, Phase Dispersions | Kyriakou et al. 2016 |
References
- CendelĂn, J., Voller, J., VoĹľeh, F. 2010. Ataxic gait analysis in a mouse model of the olivocerebellar degeneration. Behavioural Brain Research 210: 8–15. doi: 10.1016/j.bbr.2010.01.035
- Salvi, J., Bertaso, F., Mausset-Bonnefont, A.-L., Metz, A., Lemmers, C., Ango, F., Fagni, L., Lory, P., Mezghrani, A. 2014. RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2. Neurobiology of Disease 68: 47–56. doi: 10.1016/j.nbd.2014.04.005
- Kyriakou, E.I., van der Kieft, J.G., de Heer, R.C., Spink, A., Nguyen, H.P., Homberg, J.R., van der Harst, J.E. 2015. Automated quantitative analysis to assess motor function in different rat models of impaired coordination and ataxia. Journal of Neuroscience Methods 268: 171–181. doi: 10.1016/j.jneumeth.2015.12.001
Motor Coordination (Cerebellar Cortex)
Results Summary
| Result | Parameters Affected | References |
|---|---|---|
| Reduced motor coordination in mice lacking chloride calcium-gated chloride channels in Purkinje cells | Run Speed, Stride Length, Duty Cycle, Swing Speed, Stand, Print Positions, Base of Support, Footfall Patterns, Support on three paws %, Support on diagonal paws, Phase Dispersion variability | Neureither et al. 2017 |
| Deterioration of motor performance correlates with the demise of Purkinje cell axons in the cerebellum | Stride Length, Stand Duration, Swing Duration, Print Positions | Verheijden et al. 2013 |
References
- Neureither, F., Ziegler, K., Pitzer, C., Frings, S., Möhrlen, F. 2017. Impaired motor coordination and learning in mice lacking Anoctamin 2 calcium-gated chloride channels. Cerebellum (Online). doi: 10.1007/s12311-017-0867-4
- Verheijden, S., Bottelbergs, A., Krysko, O., Krysko, D.V., Beckers, L., De Munter, S., Van Veldhoven, P.P., Wyns, S., Kulik, W., Nave, K.-A., Ramer, M.S., Carmeliet, P., Kassmann, C.M., Baes, M. 2013. Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation. Neurobiology of Disease 58: 258–269. doi: 10.1016/j.nbd.2013.06.006