Research applications for DanioVision

Zebrafish are used as research models in a great variety of fields. From embryo's to adults, they have found their way into many labs. DanioVision is the ideal environment to track larval to juvenile fish.

Below you can find some of the applications DanioVision has been used for. If you want to know more about a specific validation, feel free to contact us.

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EthoVision XT tracking in DanioVision

Applications of DanioVision

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Drug Discovery

Zebrafish offer a genetically and physiologically relevant model to study disease mechanisms and screen candidate compounds. Researchers assess phenotypes, safety, and efficacy across development, often at multi-plate scale.

DanioVision enables high-throughput, multi-well tracking with integrated light and vibration stimuli for standardized assays. Combined with EthoVision XT, you capture objective locomotor and activity metrics, compare cohorts side by side, and scale screens efficiently.

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Toxicology

Toxicology examines how environmental or chemical exposures affect organism health, with zebrafish widely used to profile neurotoxic and systemic effects through behavior.

Run repeatable light/dark and LPR assays to detect subtle changes in movement, arousal, and non-associative learning. Automated stimulus control and consistent acquisition improve reproducibility, while analytics help you quantify dose–response effects.

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Circadian rhythmicity

Many behaviors follow day–night cycles, and disruptions can signal changes in neural and metabolic function. Segmenting activity by light phase helps pinpoint rhythm alterations.

Program precise light cycles and capture long-term recordings with phase-based segmentation. EthoVision XT lets you compare light vs. dark behavior, track adaptation over time, and standardize protocols across studies.

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Epilepsy

Zebrafish larvae model genetic and chemically induced seizures, allowing researchers to study network excitability and seizure-like events via behavior.

Use controlled stimuli and sensitive tracking to quantify burst activity, bout structure, and stereotypies. Standardized paradigms and synchronized logging support reliable comparisons across genotypes and treatments.

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Anxiety research

The zebrafish startle reflex is a conserved defensive response. Measuring habituation across trials reveals aspects of arousal and sensorimotor gating relevant to anxiety research.

Deliver precise taps or light cues and measure latency, magnitude, and decay over repeated presentations. EthoVision XT provides automated analysis and clear trial histories, making it easy to standardize startle protocols.

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Visual responsiveness

Assays like larval photomotor response (LPR) and phototaxis probe visual pathways and sensorimotor integration, capturing directionality and reactivity to light.

Control light color, intensity, and timing to evoke reliable responses, and track movement in complete darkness with IR when needed. Analyze directionality, adaptation, and recovery with consistent, protocol-driven tests.

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Movement disorders

Zebrafish models help interrogate motor control deficits relevant to neurodegenerative and developmental conditions, from hypokinesia to tremor-like activity.

Obtain continuous locomotor and postural metrics under controlled stimuli and environments. Detect subtle motor phenotypes using activity, speed, and bout analysis, and compare lines or treatments with confidence.

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Social preference

Zebrafish shoaling behavior as often been tested in adult zebrafish. However, juvenile fish can also show social interaction. researchers use either olfactory or other fish to measure approach vs avoicance in for example autism models.

DanioVision offers a standardized environment for measuring zebrafish behavior. Juvenile fish can be accomodated in larger wellplates and tracked within the device with EthoVision XT.

damaged nerves on spine and hips

Optogenetics

Zebrafish larvae are naturally transparent, making them ideal for light-based manipulation of neural circuits to test causal links between activity and behavior.

The Optogenetics Add-on delivers precise colors, intensities, and patterns, fully synchronized with behavioral tracking in EthoVision XT. Run activate or silence paradigms and measure immediate behavioral outcomes with unified control and logging.

The ins and outs of zebrafish research

Basic behavioral neuroscience in zebrafish

Learn all about the why, when and how regarding zebrafish development and behavior

Why should I use DanioVision?

DanioVision is a complete system designed for activity and movement patterns with zebrafish (Danio rerio) larvae, and is often used in studies related to drug development, behavioral genetics, toxicology, and circadian rhythmicity.

How do I expand my DanioVision setup?

DanioVision has range of add-ons to further broaden your experimental options, such as a temperature control unit, tapping stimulus, toplight unit, or optogenetics add-on.

Learn more about DanioVision

DanioVision has been used in thousands of publications in a variety of studies, from Parkinsons Disease, neuropharmacology, toxicology, Down syndrome, and many more.

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